ABSTRACT
BACKGROUND: The application of bone tissue engineering materials to treat bone defect diseases is a hot topic of current research. Material selection and design of in vivo experiments are the focus of research. OBJECTIVE: To summarize the research progress of bone tissue engineering materials for repairing bone defects in vivo in the past 10 years. METHODS: A search was conducted in CNKI, Wanfang, and PubMed with the key words of “bone tissue engineering, bone defect and in vivo experiment” for articles published from January 2010 to December 2019. Totally 264 articles were retrieved, and 74 eligible articles were finally summarized after screening. RESULTS AND CONCLUSION: Bone tissue engineering is a new method for treating bone defect diseases, but there are many types of bone tissue engineering materials in practical application. The single material inevitably has limitations in the application of materials. Composite materials can improve material properties and bone repair capacity. Simultaneously, the in vivo experiment is a powerful test to verify the practical application of the material, and it can detect the shortcomings that were not found in the in vitro experiments, and provide data support for the practical application of bone tissue engineering materials.